⮝ Full datasets listing
PXD071115-1
PXD071115 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Plasma proteomic signature for predicting survival in advanced HCC |
| Description | Hepatocellular carcinoma (HCC) remains one of the leading causes of cancer-related mortality globally, with over 70% of patients diagnosed at intermediate or advanced stages (BCLC B/C) where curative treatments are no longer feasible. Conventional prognostic tools fail to capture this complexity, highlighting the urgent need for precise predictive models integrating molecular and clinical data. Methods: We conducted a retrospective cohort study of 242 patients with advanced HCC (BCLC B-D) treated with first-line systemic therapy (110 deaths and 152 survivors) at admitted to the Beijing Ditan Hospital of Capital Medical University between October 2021 and December 2023. Plasma proteomic analysis was obtained using DB4000 Deep Blood DIA Proteome combined with Data Independent Acquisition (DIA) and Astral Mass Spectrometry platform. Principal component analysis and differential protein abundance analysis are used to evaluate proteomic changes between two groups of patients. ELISA quantitative verification of protein biomarker phenological selection, single-cell transcriptome sequencing analysis of the expression of target protein in HCC tissue and its relationship with prognosis. |
| HostingRepository | iProX |
| AnnounceDate | 2025-11-23 |
| AnnouncementXML | Submission_2025-11-24_00:10:01.854.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Fengna Yan |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Astral |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-11-24 00:09:42 | ID requested | |
| ⏵ 1 | 2025-11-24 00:10:02 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Plasma proteomic, HCC, BCLC B-D |
Contact List
| Yixin Hou | |
|---|---|
| contact affiliation | Beijing Ditan Hospital, Capital Medical University |
| contact email | houyixin@mail.ccmu.edu.cn |
| lab head | |
| Fengna Yan | |
| contact affiliation | Beijing Ditan Hospital, Capital Medical University, |
| contact email | m18239211525@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
