PXD070990 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Tumour Endothelial Cell Reprogramming Orchestrates Angiocrine Signalling to Drive Chemoresistance in Breast Cancer |
| Description | Phosphoproteomic analysis was performed to decipher changes occurring in tumour cells after treatment with conditioned media from endothelial cells, which may protect them from doxorubicin damage, and promote resistance to the treatment. Briefly, MMTV-PyMT (mouse mammary tumour virus-polyoma middle tumour-antigen) derived tumour cells were pretreated with conditional media from endothelial cells isolated from MMTV tumours treated with doxorubicin for 24 hours, andthen treated afterwards with vehicle (PBS) or doxorubicin in culture for 45 minutes and 2 days. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-06-29 |
| AnnouncementXML | Submission_2026-06-28_16:31:13.541.xml |
| DigitalObjectIdentifier | https://doi.org/10.6019/PXD070990 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Vinothini Rajeeve |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | phosphorylated residue; monohydroxylated residue |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-11-20 04:33:30 | ID requested | |
| ⏵ 1 | 2026-06-28 16:31:14 | announced | |
Publication List
| 10.1007/s10456-026-10063-7; |
| Gomez-Escudero J, Maniati E, Holdsworth J, Beattie G, Hijazi M, Guelbert M, Elorbany S, Cutillas P, Wang J, Hodivala-Dilke K, D'Amico G, Tumour endothelial cell reprogramming orchestrates angiocrine signalling to drive chemoresistance in breast cancer. Angiogenesis, 29(3):(2026) [pubmed] |
| 10.6019/PXD070990; |
Keyword List
| submitter keyword: doxorubicin,Phosphoproteomics,Angiocrine, chemoresistance, LC-MS/MS |
Contact List
| Maruan Hijazi Vega |
|---|
| contact affiliation | Departmento de Bioquimica Biologia Molecular Laboratorio122, Edificio Departamental Pza. Doctores de la Reina s/n 37007 Universidad de Salamanca |
| contact email | hijazivm@usal.es |
| lab head | |
| Vinothini Rajeeve |
|---|
| contact affiliation | Centre for Haemato Oncology |
| contact email | v.rajeeve@qmul.ac.uk |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD070990 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD070990
- Label: PRIDE project
- Name: Tumour Endothelial Cell Reprogramming Orchestrates Angiocrine Signalling to Drive Chemoresistance in Breast Cancer
