PXD070881-1

PXD070881 is an original dataset announced via ProteomeXchange.

Title	Proteomic and phosphoproteomic landscape underlying DGAT1 inhibitor-ameliorated lipotoxicity in Min6 cells
Description	This dataset provides a comprehensive proteomic and phosphoproteomic resource investigating the protective effects of DGAT1 inhibitors against lipotoxicity in pancreatic beta cells. Min6 cells were treated with palmitic acid (PA) to induce lipotoxicity, with or without co-treatment with the DGAT1 inhibitors. The data includes global protein expression and phosphorylation site changes, enabling the exploration of molecular mechanisms underlying PA-induced cellular stress (e.g., ER stress, inflammation) and its reversal by DGAT1 inhibition. This resource is valuable for researchers studying beta cell lipotoxicity, diabetes, lipid metabolism, and the role of DGAT1 and post-translational modifications in cell survival and ferroptosis.
HostingRepository	iProX
AnnounceDate	2025-11-18
AnnouncementXML	Submission_2025-12-31_00:16:32.441.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jiaming Guo
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	phosphorylated residue
Instrument	Q Exactive HF-X; timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2025-11-17 23:01:12	ID requested
⏵ 1	2025-12-31 00:16:32	announced

Dataset with its publication pending

submitter keyword: Min6 lipotoxicity

Hu Zhou
contact affiliation	Shanghai Institute of Materia Media
contact email	zhouhu@simm.ac.cn
lab head
Jiaming Guo
contact affiliation	Shanghai Institute of Materia Media Chinese Academy of Sciences
contact email	guojm2000@163.com
dataset submitter

iProX dataset URI