⮝ Full datasets listing
PXD070809-1
PXD070809 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Deubiquitinase OTULIN dampens RIG-I dependent type I IFN signaling by removing the linear ubiquitination from TRAF6 |
| Description | In this study, we observed a global increase in intracellular linear ubiquitination upon RNA viral infection, suggesting that linear ubiquitination may be a prerequisite for the initiation of antiviral innate immunity. Furthermore, using a combination of various cell lines and in vivo experiments, we identified OTULIN as a critical negative regulator of RNA virus-induced type I IFN signaling by specifically removing linear ubiquitin chains from TRAF6. |
| HostingRepository | iProX |
| AnnounceDate | 2025-11-15 |
| AnnouncementXML | Submission_2025-11-17_00:48:42.408.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Zhiheng Tang |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | ubiquitination signature dipeptidyl lysine |
| Instrument | LTQ Orbitrap Velos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-11-17 00:48:25 | ID requested | |
| ⏵ 1 | 2025-11-17 00:48:42 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: IP-MS, linear ubiquitination, TRAF6 |
Contact List
| Xiaoyun Liu | |
|---|---|
| contact affiliation | Peking University Health Science Center |
| contact email | xiaoyun.liu@bjmu.edu.cn |
| lab head | |
| Zhiheng Tang | |
| contact affiliation | Peking University Health Science Center |
| contact email | zhihengt@pku.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
