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PXD070763-1
PXD070763 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | MUC13-associated molecular interactome in pancreatic cancer |
| Description | MUC13 has emerged as a critical molecular player that is involved in tumorigenesis, cancer progression, metastasis and evade immune surveillance, including in pancreatic cancer. In this report, we have identified MUC13 molecular interactome using an integrated immunoprecipitation and liquid chromatography mass spectrometry (IP-LCMS) technique and systems network biology approach to determine its functional protein-protein interaction network and its associated oncogenic mechanisms. This study reveals total 54 key interactor proteins (CDK1, CTNND1, Caludin-1, ErbB3-binding protein 1, Basic transcription factor 3 and Tight junction protein 1 protein etc) of MUC13. Interestingly majority of the interacting proteins were found to be associated with oncogenic and immune checkpoint pathways. These proteins are involved in the regulation of PD1/PD-L1, T-cell receptor signaling, and post-translational protein processing and modifications in the endoplasmic reticulum. This study also revealed that MUC13 might be involved in other cellular processes such as apoptosis, autophagy, senescence, calcium signaling, microRNA activity, lysosomal function, and diabetic cardiomyopathy. Taken together, this study for the first time elucidated MUC13 associated molecular interactome that might be involved in pancreatic cancer progression and metastasis. This study will help to develop new strategies to intervene pancreatic cancer progression via disrupting MUC13 associated oncogenic molecular network. |
| HostingRepository | jPOST |
| AnnounceDate | 2025-11-15 |
| AnnouncementXML | Submission_2025-11-14_15:48:04.654.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Anupam Dhasmana |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
| ModificationList | S-carboxamidomethyl-L-cysteine; L-methionine sulfoxide; S-carboxymethyl-L-cysteine; phosphorylated L-histidine; O-phospho-L-serine; O-phospho-L-threonine; O4'-phospho-L-tyrosine |
| Instrument | orbitrap |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-11-14 15:48:00 | ID requested | |
| ⏵ 1 | 2025-11-14 15:48:05 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: MUC13, Pancreatic ductal adenocarcinoma (PDAC), Immunoprecipitation mass spectrometry (IPMS), Interactome, Functional enrichment. |
Contact List
| Subhash C. Chauhan | |
|---|---|
| lab head | |
| Anupam Dhasmana | |
| contact affiliation | University of Texas Rio Grande Valley |
| dataset submitter | |
Full Dataset Link List
| jPOST dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST004189/ |
