PXD070754-1

PXD070754 is an original dataset announced via ProteomeXchange.

Title	Blocking microglial reactivity via purinergic receptors prevents subacute cognitive deficits after TIA
Description	Our research presents a new animal model of transient ischemic attack (TIA) that mimics brief episodes without cell loss, but results in neuronal and behavioral deficits. We identified excessive microglial reactivity, driven by acute ATP release, as a key factor in post-TIA neurological deficits, which were ameliorated by inhibiting the P2Y12 receptor, a microglia-specific purinergic receptor in the brain parenchyma responsible for activity-dependent microglial cell-cell interactions. This finding suggests that modulation of microglial reactivity offers a promising strategy to prevent cognitive impairment in TIA patients, opening avenues for future research in this underexplored area.
HostingRepository	PRIDE
AnnounceDate	2026-04-24
AnnouncementXML	Submission_2026-04-24_01:17:55.628.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sebastian Kallabis
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2025-11-14 12:13:54	ID requested
⏵ 1	2026-04-24 01:17:56	announced

10.1038/S44321-026-00397-6;

submitter keyword: synapse, TIA, microglia, purinergic receptor,ATP

Arthur Liesz
contact affiliation	Institute for Stroke and Dementia Research, LMU Feodor-Lynen-Str. 17, 81377 Munich, Germany
contact email	Arthur.Liesz@med.uni-muenchen.de
lab head
Sebastian Kallabis
contact affiliation	Core Facility Translational Proteomics Medical Faculty University Bonn Venusberg - Campus 1 53127 Bonn Germany
contact email	kallabis@uni-bonn.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD070754

PRIDE project URI

• PRIDE
  1. PXD070754
     1. Label: PRIDE project
     2. Name: Blocking microglial reactivity via purinergic receptors prevents subacute cognitive deficits after TIA