PXD070627-1

PXD070627 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Human non-small cell lung cancer cell line NCI-H661 DPPA2-4 rapid immunoprecipitation mass spectrometry (RIME, LC-MSMS)
Description	To investigate DPPA2/4 bound proteins on chromatin we performed rapid immunoprecipitation mass spectrometry (RIME) following double crosslinking of chromatin in NCI-H661 non-small cell lung cancer cells clonal cell lines (Wild Type clones c51 & c52, DPPA2 knockout clones c41 & c42, DPPA4 knockout clones c78 & c79 as well as DPPA2+4 double knockout clones c08 & c14).
HostingRepository	PRIDE
AnnounceDate	2026-03-31
AnnouncementXML	Submission_2026-03-31_11:35:30.288.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Janith Seneviratne
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Astral

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-11-11 22:44:21	ID requested
⏵ 1	2026-03-31 11:35:31	announced

Publication List

Seneviratne JA, Crisp CL, Glancy E, Choy N, Tan W, Neve M, Stammers M, Wang T, Johnstone R, Kaur A, Fennell KA, Burr ML, Parker BL, Shakeel S, Eckersley-Maslin MA, Embryonic stem cell factors DPPA2/4 amplify active H3K4me3-H2AK119ub chromatin domains in non-small cell lung cancer. Genes Dev, 40(9-10):756-776(2026) [pubmed]
10.1101/gad.353102.125;

Seneviratne JA, Crisp CL, Glancy E, Choy N, Tan W, Neve M, Stammers M, Wang T, Johnstone R, Kaur A, Fennell KA, Burr ML, Parker BL, Shakeel S, Eckersley-Maslin MA, Embryonic stem cell factors DPPA2/4 amplify active H3K4me3-H2AK119ub chromatin domains in non-small cell lung cancer. Genes Dev, 40(9-10):756-776(2026) [pubmed]

10.1101/gad.353102.125;

Keyword List

submitter keyword: RIME, DPPA4, non small cell lung cancer, NCIH661, DPPA2,human

submitter keyword: RIME, DPPA4, non small cell lung cancer, NCIH661, DPPA2,human

Contact List

Melanie Eckersley-Maslin
contact affiliation	Peter MacCallum Cancer Centre, Melbourne, Australia Department of Anatomy and Physiology, The University of Melbourne, Melbourne, VIC, Australia
contact email	melanie.eckersley-maslin@petermac.org
lab head
Janith Seneviratne
contact affiliation	Peter MacCallum Cancer Centre
contact email	janith.seneviratne@petermac.org
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/03/PXD070627
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/03/PXD070627

PRIDE project URI

Repository Record List

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