PXD070605 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Tumor Agnostic Drug Delivery with Dynamic Nanohydrogels |
| Description | RNA interference (RNAi) holds unique potential as a clinically viable modality to pharmacologically regulate oncogenes in sequence-specific manner. However, systemic delivery of RNAi to tumors encounters myriad obstructions, and strategies to overcome such barriers have largely consisted of academic demonstrations with few approaches reaching patients. Here we report the development of a self-agglomerating nanohydrogel (SANGs) platform that selectively localizes to tumor tissue, is efficiently internalized by cancer cells, is agnostic to RNAi payload, and achieves functional suppression of multiple oncogene targets. After intravenous injection, SANGs preferentially accumulate and are retained in primary and metastatic loci in four aggressive cancer models in rodents. SANGs deliver multiple RNAi payloads that significantly suppress oncogene expression and sensitize previously resistant tumors while being safe and well tolerated in simulated clinical applications across three species. We propose, and provide the first direct evidence in support of, a mechanism featuring emergent material properties by which SANGs achieve durable solid-tumor delivery without attachment of cell- or tumor-targeting ligands. Overall, the SANGs platform is an enabling technology for RNAi-based cancer therapeutics and is poised for advanced pharmaceutical development with multiple solid-tumor indications. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-01-12 |
| AnnouncementXML | Submission_2026-01-11_16:27:17.285.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Nick Housley |
| SpeciesList | scientific name: Rattus norvegicus (Rat); NCBI TaxID: NEWT:10116; |
| ModificationList | iodoacetamide derivatized residue |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-11-11 14:41:22 | ID requested | |
| ⏵ 1 | 2026-01-11 16:27:18 | announced | |
Publication List
| 10.1038/s41467-025-66788-4; |
| Housley SN, Bourque AR, Matyunina LV, Panicker IA, Echeverri ES, Izykowicz M, Herrmann OA, Lee S, Arboleda JC, Jamali V, McDonald JF, Dahlman JE, Finn MG, Tumor agnostic drug delivery with dynamic nanohydrogels. Nat Commun, 17(1):184(2026) [pubmed] |
Keyword List
| submitter keyword: Nanohydrogels,RNAi, plasma, drug delivery |
Contact List
| Nick Housley |
|---|
| contact affiliation | School of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia 30332 |
| contact email | nickhousley@gatech.edu |
| lab head | |
| Nick Housley |
|---|
| contact affiliation | Georgia Tech |
| contact email | nickhousley@gatech.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD070605
- Label: PRIDE project
- Name: Tumor Agnostic Drug Delivery with Dynamic Nanohydrogels
