PXD070576 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | COL1A2 loss in placental fibroblasts drives an activated and fibrosis-like phenotype |
| Description | Preeclampsia is a serious pregnancy-induced disorder unique to humans affecting 4.6% of pregnancies worldwide. Advances in the detection, prevention and treatment of preeclampsia have been poor due to our inadequate understanding of its pathogenesis. Here, we performed a proteomics study on isolated primary pregnancy placental fibroblasts treated with siRNA against COL1A2. Loss of COL1A2 in placental fibroblasts significantly dysregulated 74 proteins (39 upregulated, 35 downregulated), which were enriched for pathways including ECM remodeling/wound healing, coagulation and fibrinolysis. Our study provides critical insight into the early pregnancy dysfunction underlying preeclampsia, opening up new avenues for predictive biomarker and preventative treatment discovery. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-06-09 |
| AnnouncementXML | Submission_2026-06-08_22:33:50.958.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Ellen Menkhorst |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Orbitrap Ascend |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-11-10 23:50:27 | ID requested | |
| ⏵ 1 | 2026-06-08 22:33:51 | announced | |
Publication List
| Menkhorst E, Yang G, Yu Y, Santos LL, Zhou W, Syngelaki A, Varshney S, Williamson NA, Koga K, Rolnik DL, da Silva Costa F, Nicolaides K, L, ê, Cao KA, Dimitriadis E, Multi-Omics Reveals Early Pregnancy Placental Dysfunction Associated With Preterm and Term Preeclampsia. MedComm (2020), 7(6):e70784(2026) [pubmed] |
| 10.1002/mco2.70784; |
Keyword List
| submitter keyword: Placenta, COL1A2, fibroblast |
Contact List
| Ellen Menkhorst |
|---|
| contact affiliation | Department of Obstetrics, Gynecology and Newborn Health; The University of Melbourne |
| contact email | ellen.menkhorst@unimelb.edu.au |
| lab head | |
| Ellen Menkhorst |
|---|
| contact affiliation | University of Melbourne |
| contact email | ellen.menkhorst@unimelb.edu.au |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD070576
- Label: PRIDE project
- Name: COL1A2 loss in placental fibroblasts drives an activated and fibrosis-like phenotype
