PXD070553-1

PXD070553 is an original dataset announced via ProteomeXchange.

Title	Comparative analysis of tear proteomics in PAX6 mutant and control mice of both sexes before and after abrasion
Description	Our team is working on aniridia, an autosomal dominant condition and has used a mouse model. The cornea, the eye’s first avascular and transparent optical surface, is covered by a stratified epithelium that constantly renews itself; any disruption compromises transparency and threatens vision. The tear film, rich in growth factors, protects and nourishes the corneal surface, and proteomic analysis enables global evaluation in normal and pathological states. The transcription factor PAX6 is essential for ocular development, including the lacrimal gland; its mutations cause diverse malformations and, at the corneal level, lead to progressive limbal stem cell deficiency with opacification and fibrosis, along with chronic inflammation and tear film abnormalities. Current treatments for dry eye in this context remain non-specific (artificial tears, cyclosporine, punctal plugs, scleral lenses). Identifying precise qualitative alterations of the tear film is a key step toward designing targeted therapies, such as protein-based eye drops to preserve the cornea in patients with PAX6 mutations. This project is part of a broader study aimed at evaluating the impact of a pathogenic heterozygous PAX6 mutation on the corneal and lacrimal phenotype of mice. We are interested in development, adult phenotype, and healing mechanisms following corneal injury. In this context, we performed a comparative proteomic analysis of tears in PAX6 mutant and control mice of both sexes before and after abrasion.
HostingRepository	PRIDE
AnnounceDate	2026-06-01
AnnouncementXML	Submission_2026-05-31_20:46:01.720.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jana Kindermans
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	iodoacetamide derivatized residue
Instrument	timsTOF HT

Revision	Datetime	Status	ChangeLog Entry
0	2025-11-10 09:56:55	ID requested
⏵ 1	2026-05-31 20:46:02	announced

Willems M, Girard M, Feret N, Touchet D, Vialaret J, Kindermans J, Fichter L, Hirtz C, Bremond-Gignac D, Daien V, Delettre C, Pequignot M, Michon F, Sexual Dimorphism Is Associated With Corneal Nerve and Epithelial Alterations and Tear-Film Defects in Pax6 Haploinsufficiency Mouse Model. Invest Ophthalmol Vis Sci, 67(5):39(2026) [pubmed]

10.1167/iovs.67.5.39;

submitter keyword: tear proteomics, wound healing, PAX6,aniridia

Christophe HIRTZ
contact affiliation	LBPC-PPC, Montpellier University, IRMB CHU Montpellier, INM INSERM, Montpellier, Occitanie, France
contact email	christophe.hirtz@umontpellier.fr
lab head
Jana Kindermans
contact affiliation	PPC - CHU Montpellier Saint-Eloi
contact email	j-kindermans@chu-montpellier.fr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD070553

PRIDE project URI

• PRIDE
  1. PXD070553
     1. Label: PRIDE project
     2. Name: Comparative analysis of tear proteomics in PAX6 mutant and control mice of both sexes before and after abrasion