PXD070547-1

PXD070547 is an original dataset announced via ProteomeXchange.

Title	A comprehensive landscape of human organ N-glycoproteome
Description	N-glycosylation, as a common post-translational modification with enormous structures, plays key roles in protein folding, cellular recognition and signaling pathways. State-of-the-art mass spectrometry-based N-glycoproteomics has enabled deep N-glycoproteome characterization of various human organs. However, a comprehensive N-glycoproteome landscape of human organs remains lacking. Here we present a systematic human N-glycoproteome atlas spanning 18 organs/tissues with identification of 31,003 intact N-glycopeptides, corresponding to 14,043 N-glycan monosaccharide compositions on 5,539 N-glycosites of 3,681 N-glycoproteins. Tissue-specific glycosylation patterns, novel glycoforms and crosstalk between sialylation and fucosylation are observed. This atlas, complemented by a unified multi-software analysis framework, provides insights into organ-specific glycobiology and establishes a fundamental reference for understanding physiological glycosylation characteristics of human tissues.
HostingRepository	PRIDE
AnnounceDate	2026-05-13
AnnouncementXML	Submission_2026-05-13_13:09:02.649.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	hu xiaoyu
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2025-11-10 08:05:39	ID requested
⏵ 1	2026-05-13 13:09:03	announced

Dataset with its publication pending

submitter keyword: tissue, human,N-glycosylation, profile

Zhixin Tian
contact affiliation	School of Chemical Science & Engineering, Tongji University, Shanghai 200092, China
contact email	zhixintian@tongji.edu.cn
lab head
hu xiaoyu
contact affiliation	18021053630
contact email	2111204@tongji.edu.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD070547

PRIDE project URI

• PRIDE
  1. PXD070547
     1. Label: PRIDE project
     2. Name: A comprehensive landscape of human organ N-glycoproteome