PXD070542 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Plasma proteome profiling of Osteoporosis Sarcopenia (OsteoSarc) cohort |
| Description | Sarcopenia is an age-related condition characterized by progressive decline in muscle mass, strength, and physical performance, contributing to frailty and adverse health outcomes. Despite increasing interest in molecular biomarkers, longitudinal data with external validation are limited. This study utilized high-throughput proteomic analysis to identify and validate biomarkers associated with progression of sarcopenia in two independent prospective cohorts. The OsteoSarc cohort (n=93) was followed up for two years. Plasma proteomic profiling was conducted using data-independent acquisition (DIA) mass spectrometry. Statistical analyses included multivariable regression, principal component analysis, and pathway enrichment. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-03-09 |
| AnnouncementXML | Submission_2026-03-08_19:50:59.367.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Dohyun Han |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-11-10 07:03:31 | ID requested | |
| ⏵ 1 | 2026-03-08 19:51:00 | announced | |
Publication List
| 10.1002/jcsm.70240; |
| Kong SH, Jeon OH, Kim JY, Kim M, Kim J, Park SS, Chang HC, Won CW, Han D, Distinct Proteomic Signatures Driving Progression of Sarcopenia: A Longitudinal Multicohort Study. J Cachexia Sarcopenia Muscle, 17(2):e70240(2026) [pubmed] |
Keyword List
| submitter keyword: Plasma, DIA, Sarcopenia |
Contact List
| Dohyun Han |
|---|
| contact affiliation | Proteomics and Metabolomics Core Facility, Biomedical Research Institute, Seoul National University Hospital |
| contact email | hdh03@snu.ac.kr |
| lab head | |
| Dohyun Han |
|---|
| contact affiliation | Proteomics Core Facility, Biomedical Research Institute, Seoul National University Hospital |
| contact email | hdh03@snu.ac.kr |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/03/PXD070542 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD070542
- Label: PRIDE project
- Name: Plasma proteome profiling of Osteoporosis Sarcopenia (OsteoSarc) cohort
