PXD070525-1

PXD070525 is an original dataset announced via ProteomeXchange.

Title	Aurintricarboxylic acid safely inhibits multiple cancers by inhibiting translation initiation
Description	This study introduces a therapeutic strategy that simultaneously addresses four fundamental challenges in oncology: efficacy, safety, the emergence of drug resistance, and pan-cancer applicability. We demonstrate that aurintricarboxylic acid (ATCA) suppresses malignant phenotypes across a diverse range of cancers by targeting the hyperactive translation initiation machinery, a universal hallmark of cancer. This core mechanism underpins its validated efficacy in lung, breast, colorectal, and liver carcinomas, while its unique action of disrupting ribosome assembly without stalling them underlies its exceptional safety profile and formidable barrier to resistance. The significance of our work is underscored by several key findings:
HostingRepository	iProX
AnnounceDate	2025-11-10
AnnouncementXML	Submission_2025-11-10_01:20:02.975.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jiamin Li
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2025-11-10 01:19:49	ID requested
⏵ 1	2025-11-10 01:20:03	announced

Dataset with its publication pending

submitter keyword: Aurintricarboxylic acid, anti-cancer drug, translation initiation inhibition

Gong Zhang
contact affiliation	Jinan University
contact email	zhanggong@jnu.edu.cn
lab head
Jiamin Li
contact affiliation	Jinan University
contact email	320884946@qq.com
dataset submitter

iProX dataset URI