PXD070479 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Exoproteome remodeling by the BraI/R Quorum Sensing circuit and interspecies competition in Paraburkholderia |
| Description | Quorum sensing (QS) is a cell-to-cell communication mechanism that enables bacteria to coordinate collective behaviors in response to population density. The BraI/R QS system is conserved among Burkholderia and Paraburkholderia species, and its regulatory role is still unknown. In this study, the BraI/R QS of P. kururiensis was investigated for biological control of another bacterial species. The results demonstrate that the functional BraI/R system influences interbacterial competition, as braI and braR mutant strains failed to inhibit the growth of Escherichia coli, in contrast to the wild-type strain. These findings suggest that the BraI/R QS system plays a regulatory role in modulating interspecies antagonism. Comparative exoproteome analyses were performed for the wild-type and the BraI/R QS-mutant P. kururiensis strains, revealing distinct protein populations, including structural and effector proteins of the Type VI secretion system (T6SS). Genomic mapping revealed that two of those T6SS-proteins were encoded within a specific T6SS gene cluster (T6SS-3), while others originate outside any major T6SS gene cluster. The identification of exoproteome targets regulated by the BraI/R QS system represents a significant advance toward the understanding of the molecular mechanisms underpinning P. kururiensis interactions with competing bacteria, further supporting its potential as a biological control agent against phytopathogenic and/or free-living species. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-07-29 |
| AnnouncementXML | Submission_2026-07-29_11:26:19.918.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Proteomics Unit |
| SpeciesList | scientific name: Paraburkholderia kururiensis M130; NCBI TaxID: NEWT:1268285; |
| ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Q Exactive Plus |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-11-07 15:23:51 | ID requested | |
| ⏵ 1 | 2026-07-29 11:26:20 | announced | |
Publication List
Keyword List
| submitter keyword: Paraburkholderia, Type VI Secretion System, Quorum Sensing, Proteomics, Biological Control. |
Contact List
| Fábio C. S. Nogueira |
|---|
| contact affiliation | Institute of Chemistry, Federal University of Rio de Janeiro, Brazil. |
| contact email | fabiocsn@iq.ufrj.br |
| lab head | |
| Proteomics Unit |
|---|
| contact affiliation | UFRJ |
| contact email | unidadeproteomica@gmail.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD070479
- Label: PRIDE project
- Name: Exoproteome remodeling by the BraI/R Quorum Sensing circuit and interspecies competition in Paraburkholderia
