PXD070456-1

PXD070456 is an original dataset announced via ProteomeXchange.

Title	Targeting Secondary Muscle Atrophy to Enhance Motor Recovery in Experimental Autoimmune Neuritis
Description	Secondary muscle atrophy due to neuronal denervation is a key determinant of poor functional recovery in immune-mediated neuropathies, even after resolution of inflammation. Activin II receptors (ActIIRs) are central mediators of muscle atrophy, and their inhibition has shown variable efficacy in primary myopathies. We investigated the therapeutic potential of ActIIR inhibition in promoting motor recovery in immune-mediated neuropathies using the experimental autoimmune neuritis (EAN) model in Lewis rats. Motor performance was evaluated through a composite of clinical neuritis scoring, grip strength testing, and balance beam performance combined with kinematic gait analysis. High-dose antibody treatment significantly improved motor outcome. This improvement was not associated with changes in peripheral nerve inflammation or remyelination but correlated with preservation of muscle fiber size. Muscle proteomic analysis revealed modulation of the FoxO signaling pathway and reduced expression of the atrophy-related E3 ligases Atrogin-1 and MuRF1. These findings indicate that ActIIR inhibition prevents secondary muscle atrophy and enhances motor recovery in autoimmune neuritis. Targeting ActIIR signaling may represent a promising therapeutic strategy to improve motor outcomes in patients with immune-mediated neuropathies.
HostingRepository	PRIDE
AnnounceDate	2026-04-13
AnnouncementXML	Submission_2026-04-12_16:18:40.468.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Proteomics Facility
SpeciesList	scientific name: Rattus rattus (Black rat); NCBI TaxID: NEWT:10117;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2025-11-07 06:34:22	ID requested
⏵ 1	2026-04-12 16:18:41	announced

10.1186/s40478-026-02277-z;

Gerlach I, Koch M, Gatto G, Lackmann JW, Lehmann HC, Schroeter M, Kohle F, ActIIR inhibition improves motor outcome and preserves muscle fibers after experimental autoimmune neuritis. Acta Neuropathol Commun, 14(1):(2026) [pubmed]

submitter keyword: Neuropathy, Autoimmune Neuritis,Muscle Atrophy

Prof. Michael Schroeter
contact affiliation	Department of Neurology, Faculty of Medicine, University of Cologne and University Hospital Cologne, Kerpener Strasse 62, 50937 Cologne, Germany
contact email	Michael.schroeter@uk-koeln.de
lab head
Proteomics Facility
contact affiliation	CECAD Research Center
contact email	proteomics-facility@uni-koeln.de
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD070456
     1. Label: PRIDE project
     2. Name: Targeting Secondary Muscle Atrophy to Enhance Motor Recovery in Experimental Autoimmune Neuritis