⮝ Full datasets listing
PXD070443-1
PXD070443 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Andrographolide attenuates microglial senescence in a 5×FAD mouse model of Alzheimer's disease by suppressing the STAT3 signaling pathway |
| Description | Andrographolide (AP), a diterpenoid compound extracted from Andrographis paniculata, has been shown to be a promising therapy for Alzheimer's disease (AD) in preclinical studies, but the involved mechanisms still need to be clarified. Here we showed that AP improved cognition function and reduced amyloid-β (Aβ) plaque accumulation of 5×FAD transgenic mice by mitigating microglial senescence. |
| HostingRepository | iProX |
| AnnounceDate | 2025-11-06 |
| AnnouncementXML | Submission_2025-11-06_23:52:07.888.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Hao Chang |
| SpeciesList | scientific name: Mus |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Astral |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-11-06 23:51:50 | ID requested | |
| ⏵ 1 | 2025-11-06 23:52:08 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Alzheimer’s disease, 5×FAD, Andrographolide, Microglia senescence, Cholesterol metabolism, STAT3 |
Contact List
| Gonghua Huang | |
|---|---|
| contact affiliation | Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics |
| contact email | gonghua.huang@gdmu.edu.cn |
| lab head | |
| Hao Chang | |
| contact affiliation | Guangdong Medical University |
| contact email | 2464047868@qq.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
