PXD070431-2

PXD070431 is an original dataset announced via ProteomeXchange.

Title	Whole proteome measurement to determine effects of USP7 targeting small molecules in pancreatic cancer cells (Panc89) and melanoma cells (MaMel47)
Description	Whole Proteome measurement of pancreatic cancer cells (Panc89) or melanoma cells (MaMel47) treated with USP7 inhibitors and degrader to compare phenotypes induced by inhibition compared to degradation. We synthesized and characterized potent USP7-targeting degrader molecules (PROTACs) and compared USP7 degradation to inhibition
HostingRepository	PRIDE
AnnounceDate	2026-05-18
AnnouncementXML	Submission_2026-05-18_05:40:12.735.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Farnusch Kaschani
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2025-11-06 21:10:20	ID requested
1	2026-04-20 23:35:59	announced
⏵ 2	2026-05-18 05:40:13	announced	2026-05-18: Updated project metadata.

10.1038/s41467-026-72295-x;

Klink N, Urban S, Seier JA, Adhikari B, Schwalm MP, M, ü, ller J, Dorsch M, Steinbach P, Jung J, Vogt M, Kaschani F, Koch J, F, ü, hrer S, Kaiser M, Schulze N, Knapp S, Wolf E, Paschen A, Gr, ü, ner BM, Gersch M, Targeted degradation of USP7 in solid cancer cells reveals distinct effects of deubiquitinase degraders and inhibitors. Nat Commun, 17(1):(2026) [pubmed]

submitter keyword: MaMel47, Panc89, LC-MS, USP7-targeting degrader, PROTAC

Farnusch Kaschani
contact affiliation	Analytics Core Facility Essen (ACE), Chemische Biologie, Universität Duisburg-Essen, ZMB, Germany
contact email	farnusch.kaschani@uni-due.de
lab head
Farnusch Kaschani
contact affiliation	University Duisburg-Essen
contact email	farnusch.kaschani@uni-due.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD070431

PRIDE project URI

• PRIDE
  1. PXD070431
     1. Label: PRIDE project
     2. Name: Whole proteome measurement to determine effects of USP7 targeting small molecules in pancreatic cancer cells (Panc89) and melanoma cells (MaMel47)