PXD070417 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Microglial Adaptations to Chronic Nicotine in the Cerebellum: Proteomic Evidence for Neuroimmune Vulnerability |
| Description | In this study, we investigated how chronic nicotine exposure reshapes microglial proteomes in the cerebellum using fluorescence-activated cell sorting (FACS) and mass spectrometry-based proteomics in adult male and female mice following 30 days of nicotine exposure. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-06-08 |
| AnnouncementXML | Submission_2026-06-07_16:20:35.074.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Aya Nusir |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-11-06 12:11:21 | ID requested | |
| ⏵ 1 | 2026-06-07 16:20:35 | announced | |
Publication List
| Nusir A, Anthony SM, Zhou W, Kabbani N, Microglial Adaptations to Chronic Nicotine in the Cerebellum: Proteomic Evidence for Neuroimmune Vulnerability. J Proteome Res, 25(5):2359-2373(2026) [pubmed] |
| 10.1021/acs.jproteome.5c01027; |
Keyword List
| submitter keyword: sex differences, inflammation,addiction, smoking, neurodegeneration |
Contact List
| Nadine Kabbani |
|---|
| contact affiliation | Interdisciplinary Program in Neuroscience, School of Systems Biology, George Mason University, Fairfax, VA 22030, USA |
| contact email | nkabbani@gmu.edu |
| lab head | |
| Aya Nusir |
|---|
| contact affiliation | George Mason University |
| contact email | anusir@gmu.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD070417 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD070417
- Label: PRIDE project
- Name: Microglial Adaptations to Chronic Nicotine in the Cerebellum: Proteomic Evidence for Neuroimmune Vulnerability
