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PXD070400-1
PXD070400 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | N-terminal α-Amino SUMOylation Promotes Phosphorylation-Independent Cofilin-1 Translocation to the Mitochondrial Matrix and Induces Apoptosis |
| Description | Cofilin (CFL) is a key regulator of actin dynamics that primarily governs the transition between filamentous actin (F-actin) and globular actin (G-actin) through phosphorylation. Beyond its established role in cytoskeletal remodeling, we investigate CFL1’s involvement in mitochondrial dynamics, emphasizing N-terminal α-amino SUMOylation, which enhances mitochondrial translocation via Tom20/Tom70 interactions mediated by HSP70. These findings challenge the conventional paradigm that CFL1 activity is driven solely by phosphorylation and actin binding, revealing an actin-independent mechanism influencing mitochondrial integrity and apoptosis initiation. Moreover, our study identifies that CFL1’s localization in the mitochondrial matrix is a critical determinant of mitochondrial dysfunction and cytochrome c (Cyt c) release. SUMOylated CFL1 interacts with cytochrome c1 (CYC1), promoting Cyt c release and apoptosis. This work offers new insights into the regulation of mitochondrial apoptosis and suggests potential therapeutic strategies targeting mitochondrial dysfunction and aberrant apoptotic pathways. |
| HostingRepository | iProX |
| AnnounceDate | 2025-11-06 |
| AnnouncementXML | Submission_2025-11-06_00:58:06.751.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Qi Deng |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive Plus |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-11-06 00:57:47 | ID requested | |
| ⏵ 1 | 2025-11-06 00:58:07 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: SUMOylation, CFL1 |
Contact List
| Yong Li | |
|---|---|
| contact affiliation | Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine |
| contact email | 19940226abc@sjtu.edu.cn |
| lab head | |
| Qi Deng | |
| contact affiliation | Shanghai Jiao Tong University of Medicine |
| contact email | 19940226abc@sjtu.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
