PXD070301-1

PXD070301 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Proteomics analysis of myocardial tissue from ischemia/reperfusion (I/R) pig model treated with cardiosphere-derived cells (CDCs)
Description	Some studies report better outcomes in cell therapy for myocardial infarction (MI) with repeated administrations. We aimed to elucidate the potential differences in terms protein expression after one or three doses of cardiosphere-derived cells (CDCs) in a porcine MI model. CDCs were isolated from swine cardiac explants, cultured in CGM, and prepared for administration. Pigs surviving a 90-minute balloon occlusion of the mid-LAD were randomly allocated to receive vehicle (CON), one (D1) or three (D3) doses of 30x106 CDCs via the infarct-related coronary artery.
HostingRepository	PRIDE
AnnounceDate	2025-12-22
AnnouncementXML	Submission_2025-12-21_17:26:02.746.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Inmaculada Jorge
SpeciesList	scientific name: Sus scrofa domesticus (domestic pig); NCBI TaxID: NEWT:9825;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-11-04 08:13:35	ID requested
⏵ 1	2025-12-21 17:26:03	announced

Publication List

de Pedro M Á, B, á, ez-D, í, az C, Jorge I, V, á, zquez-Lopez F, Torrescusa-Bermejo A, Martinez-Fernandez B, Pulido M, L, ó, pez E, V, á, zquez J, S, á, nchez-Margallo FM, Crisostomo V, Administration of Single or Repeated Doses of CDCs in a Swine Model of Reperfused Myocardial Infarction: Magnetic Resonance and Proteomics Evaluation. Int J Mol Sci, 26(23):(2025) [pubmed]
10.3390/ijms262311294;

de Pedro M Á, B, á, ez-D, í, az C, Jorge I, V, á, zquez-Lopez F, Torrescusa-Bermejo A, Martinez-Fernandez B, Pulido M, L, ó, pez E, V, á, zquez J, S, á, nchez-Margallo FM, Crisostomo V, Administration of Single or Repeated Doses of CDCs in a Swine Model of Reperfused Myocardial Infarction: Magnetic Resonance and Proteomics Evaluation. Int J Mol Sci, 26(23):(2025) [pubmed]

10.3390/ijms262311294;

Keyword List

submitter keyword: Quantitative proteomics, I/R pig model, TMT18plex, cardiosphere-derived cells

submitter keyword: Quantitative proteomics, I/R pig model, TMT18plex, cardiosphere-derived cells

Contact List

Jesús Vázquez Cobos
contact affiliation	Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)
contact email	jvazquez@cnic.es
lab head
Inmaculada Jorge
contact affiliation	Cardiovascular Proteomics Lad. Spanish National Center for Cardiovascular Research (CNIC). Madrid.
contact email	ijorge@cnic.es
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/12/PXD070301
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/12/PXD070301

PRIDE project URI

Repository Record List

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