PXD070273 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomic profiling of SLIP-mediated mucus barrier restoration in Agr2 KO and DSS-induced colitis |
| Description | This dataset examines the proteomic mechanisms by which synthetic mucin polymers (Shear-Labile Interaction Polymers, SLIPs) restore intestinal barrier integrity and modulate inflammation in chronic and acute colitis models. In the Agr2 KO model of chronic mucus deficiency, colon and spleen proteomes were analyzed following SLIP treatment to assess molecular recovery of mucosal and systemic homeostasis. In the DSS-induced model of acute epithelial injury, distal colon proteomes were compared between SLIP-treated and untreated mice during the recovery phase. Quantitative LC–MS/MS analyses revealed that SLIPs attenuate NF-κB and interferon-driven immune cascades, restore mitochondrial and redox pathways, and promote epithelial differentiation and mucus-associated repair. Together, these datasets define the molecular outcomes of artificial mucin therapy in distinct forms of gut barrier dysfunction. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-06-01 |
| AnnouncementXML | Submission_2026-06-01_15:11:12.223.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Jessica Xhumari |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-11-03 19:54:13 | ID requested | |
| ⏵ 1 | 2026-06-01 15:11:12 | announced | |
Publication List
Keyword List
| submitter keyword: Colon, Gut barrier, SLIPs, Inflammation, DSS, Proteome Discoverer, Epithelial repair,Mouse, Label-free quantification, Spleen, Agr2 knockout, Synthetic mucin, Orbitrap, LC–MS/MS |
Contact List
| Luiz Fernando Wurdig Roesch |
|---|
| contact affiliation | Microbiology and Cell Science Universiy of Florida |
| contact email | roesch@ufl.edu |
| lab head | |
| Jessica Xhumari |
|---|
| contact affiliation | University of Florida |
| contact email | jessicaxhumari@ufl.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD070273 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD070273
- Label: PRIDE project
- Name: Proteomic profiling of SLIP-mediated mucus barrier restoration in Agr2 KO and DSS-induced colitis
