⮝ Full datasets listing
PXD070267-1
PXD070267 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | The Application of Salidroside@T-exo Regulated by the PI3K/AKT/mTOR Pathway in the Remodeling of the Immune Microenvironment in Breast Cancer |
| Description | Breast cancer (Breast Cancer, BC) patients often face the issue of acquired resistance during PD-1 immunotherapy, which significantly limits the efficacy and durability of treatment. Research indicates that the tumor immune microenvironment is closely linked to the development of resistance. To address this challenge, this study aims to regulate the PI3K/AKT/mTOR signaling pathway by using Salidroside-loaded oligopeptide-modified tumor stem cell-derived exosomes (Salidroside@T-exo), thereby reshaping the immune microenvironment of breast cancer and reversing PD-1 immunotherapy resistance. We modified the oligopeptide TMTP1 onto the surface of tumor stem cell exosomes and introduced Salidroside via electroporation to prepare Salidroside@T-exo. The experiment involved in vitro construction of a MA782/5s-8101 PD-1-resistant cell model, combined with high-throughput sequencing, proteomics, and metabolomics analyses, to investigate the effects of Salidroside@T-exo on tumor cell proliferation, metabolism, and the immune microenvironment. The results demonstrated that Salidroside@T-exo significantly inhibited the activity of the PI3K/AKT/mTOR signaling pathway, enhanced T cell proliferation and tumor cell-killing capacity, reshaped the immune microenvironment, and successfully reversed PD-1 resistance. Our study provides an innovative therapeutic strategy for breast cancer, which may help improve the efficacy of immunotherapy. |
| HostingRepository | iProX |
| AnnounceDate | 2025-11-04 |
| AnnouncementXML | Submission_2025-11-03_18:47:18.509.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Faxiang Yin |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | LTQ |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-11-03 18:46:45 | ID requested | |
| ⏵ 1 | 2025-11-03 18:47:19 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: PI3K, AKT, mTOR |
Contact List
| Jun Qian | |
|---|---|
| contact affiliation | Anhui Medical University |
| contact email | byqianjun01056@163.com |
| lab head | |
| Faxiang Yin | |
| contact affiliation | Anhui Medical University |
| contact email | 1545559471@qq.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
