PXD070260-1

PXD070260 is an original dataset announced via ProteomeXchange.

Title	Mitochondrial Proteomics Uncovers Myeloid S100A9 Deficiency Promotes Liver Injury and Fibrosis Regression via Mitochondrial Metabolic Reprogramming of Macrophages
Description	Macrophage-mediated inflammation has been implicated in the pathogenesis of liver fibrosis. Metabolic reprogramming involves in the transition of macrophages from a pro-inflammatory M1-phenotype toward an anti-inflammatory M2-phenotype. S100A9 is highly expressed in activated macrophages and promotes M1 polarization, however, it is unknown whether S100A9 alters the polarization state of macrophages by regulating metabolism. This study revealed enhanced oxidative phosphorylation (OXPHOS) in S100a9-deficient macrophages based on mitochondrial proteomics, characterized by increased mitochondrial fusion and elevated ATP production.
HostingRepository	iProX
AnnounceDate	2025-11-03
AnnouncementXML	Submission_2025-11-03_17:02:42.691.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jinfang Liu
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2025-11-03 17:02:29	ID requested
⏵ 1	2025-11-03 17:02:43	announced

Dataset with its publication pending

submitter keyword: Mitochondrial Proteomics

Ping Xu
contact affiliation	National center for protein sciences(Beijing)&Beijing Proteome Research Center)
contact email	xuping_bprc@126.com
lab head
Jinfang Liu
contact affiliation	Wuhan University & National Center for Protein Sciences (Beijing) & Beijing Proteome Research Center
contact email	liujinfang1993@163.com
dataset submitter

iProX dataset URI