PXD070229 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Evaluation of Ca37 monoclonal antibody against pathogenic fungal Candidozyma auris |
| Description | Candidozyma auris, previously known as Candida auris, is a recently found pathogenic yeast that causes systemic infections, showing a high mortality rate. Moreover, this species is highly resistant to the commonly used antifungal drugs and some of the strains are multiresistant. This fungus is also able to cause outbreaks in hospital settings. All of this has cause an alarm in the health care system. Therefore, finding alternative treatments for C. auris is critical. In this sense, our research group developed a monoclonal antibody (Ca37) against Candida albicans alcohol dehydrogenase enzyme (Adh) that successfully reduced the growth of the fungus in vitro and also showed a protective effect in vivo. Due to the high homology between both fungal alcohol dehydrogenases, we wanted to test the effect of Ca37 over C. auris. In order to do this, first we assessed if the monoclonal antibody also recognized C. auris Adh by sequencing the spots detected by two dimensional western blot when using the monoclonal antibody as first antibody. Two spots were detected in this western blot. The sequencing showed a mixture of proteins, but in both cases, Adh was one of the identified proteins. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-01-05 |
| AnnouncementXML | Submission_2026-01-04_16:08:23.235.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Aitziber Antoran |
| SpeciesList | scientific name: [Candida] auris; NCBI TaxID: NEWT:498019; |
| ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Orbitrap Exploris 240 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-11-03 07:43:12 | ID requested | |
| ⏵ 1 | 2026-01-04 16:08:24 | announced | |
Publication List
| 10.3390/jof11120864; |
| Rodriguez-Erenaga O, Areitio M, Abio-Dorronsoro L, Cazalis-Bereicua N, Aparicio-Fernandez L, Martin-Souto L, Buldain I, Zaldibar B, Rementeria A, Antoran A, Ramirez-Garcia A, ) In Vitro and In Vivo. J Fungi (Basel), 11(12):(2025) [pubmed] |
Keyword List
| submitter keyword: Fungi, Candidozyma auris, alcohol deshydrogenase, Monoclonal antibody |
Contact List
| Andoni Ramirez Garcia |
|---|
| contact affiliation | Dept. Immunology, Microbiology and Parasitology Faculty of Science and Technology University of the Basque Country (UPV/EHU) Leioa, Spain |
| contact email | andoni.ramirez@ehu.eus |
| lab head | |
| Aitziber Antoran |
|---|
| contact affiliation | University of the Basque Country (UPV/EHU) |
| contact email | aitziber.antoran@ehu.eus |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/01/PXD070229 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD070229
- Label: PRIDE project
- Name: Evaluation of Ca37 monoclonal antibody against pathogenic fungal Candidozyma auris
