PXD070212-1

PXD070212 is an original dataset announced via ProteomeXchange.

Title	Thymol and carvacrol alleviate intestinal inflammation in lambs via the Romboutsia maritimum-benzyl cinnamate-GALNT7/MUC2 axis
Description	Dietary supplementation with thymol and carvacrol (CAT) effectively mitigated intestinal inflammation in diarrheic lambs. Multi-omics integrative analyses demonstrated that CAT selectively enriched Romboutsia maritimum, whose metabolic activity led to the production of benzyl cinnamate—a microbial metabolite with potent anti-inflammatory properties. Mechanistically, benzyl cinnamate activated the host glycosyltransferase GALNT7 to upregulate MUC2 expression, thereby promoting mucosal barrier restoration and counteracting E. coli (O157:H7)–induced intestinal injury.
HostingRepository	iProX
AnnounceDate	2025-11-03
AnnouncementXML	Submission_2026-05-06_18:18:04.864.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jinrui Zhang
SpeciesList	scientific name: Capra hircus; NCBI TaxID: 9925;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Astral

Revision	Datetime	Status	ChangeLog Entry
0	2025-11-03 00:29:53	ID requested
⏵ 1	2026-05-06 18:18:05	announced

Dataset with its publication pending

submitter keyword: Thymol and Carvacrol , IBD, Intestinal Mucosal Barrier, Romboutsia maritimum，Benzyl cinnamate,GALNT7--MUC2 axis

Yuxin Yang
contact affiliation	Northwest Agriculture and Forestry University
contact email	yangyuxin2002@126.com
lab head
Jinrui Zhang
contact affiliation	Northwest Agriculture and Forestry University
contact email	kekourui@163.com
dataset submitter

iProX dataset URI