PXD070152 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Determining changes in the oxidized proteome of human CD8+ T cells with enhancing proteasome activity |
| Description | Chronic T cell receptor (TCR) stimulation, combined with adverse conditions in the tumor microenvironment (TME) such as hypoxia and nutrient deprivation, frequently results in T cell exhaustion. Exhausted T cells (TEX) experience oxidative stress, which causes an accumulation of oxidized proteins within the cells. We hypothesized that oxidized protein formation might exceed proteasomal degradation capacity, leading to their accumulation and impairing TEX cell fitness. By pharmacologically boosting proteasome activity, we decreased the accumulation of oxidized proteins, delaying T exhaustion and enhancing T cell fitness, resulting in superior anti-tumor control. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-03-12 |
| AnnouncementXML | Submission_2026-03-12_01:10:34.356.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Mikel Azkargorta |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF HT |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-10-31 08:53:26 | ID requested | |
| ⏵ 1 | 2026-03-12 01:10:34 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Exhausted T cells (TEX), oxidative stress, proteasome |
Contact List
| Felix Elortza |
|---|
| contact affiliation | Proteomics Pltaform CIC bioGUNE Bizkaia Tech. Park Build. 800 48160 Derio Spain |
| contact email | felortza@cicbiogune.es |
| lab head | |
| Mikel Azkargorta |
|---|
| contact affiliation | Proteomics Platform CIC bioGUNE |
| contact email | mazkargorta@cicbiogune.es |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/03/PXD070152 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD070152
- Label: PRIDE project
- Name: Determining changes in the oxidized proteome of human CD8+ T cells with enhancing proteasome activity
