PXD070149 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Integration of Multiple Spatial Omics Modalities Reveals Unique Insights into Molecular Heterogeneity of Prostate Cancer |
| Description | This project introduces a spatial multi-omics (SMOx) pipeline integrating MALDI-2 mass spectrometry imaging (MSI) with Visium spatial transcriptomics (ST) and single-nucleus RNA sequencing (snRNA-seq) to investigate molecular heterogeneity in human prostate cancer (PCa). MALDI-2 MSI was used to map lipid distributions with enhanced sensitivity compared to conventional MALDI, enabling detailed visualization of metabolic alterations across tissue regions. Through non-rigid co-registration via H&E images and Gaussian-weighted granularity matching, MSI data were spatially aligned with transcriptomic and histological layers. This integration revealed lipid–gene expression relationships associated with distinct cell populations and pathological states within heterogeneous prostate tissues. The resulting dataset provides a high-resolution molecular atlas of PCa, demonstrating the power of MSI-driven spatial multi-omics to uncover lipid-based signatures that refine tissue annotation and support molecular pathology studies. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-10-31 |
| AnnouncementXML | Submission_2025-10-31_07:47:57.389.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Lorenzo Venturelli |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | LTQ Orbitrap Elite |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-10-31 05:29:04 | ID requested | |
| ⏵ 1 | 2025-10-31 07:47:57 | announced | |
Publication List
Keyword List
| submitter keyword: Human Tissue,Prostate Cancer, MALDI, MSI, Multi-Omics |
Contact List
| Johan Swinnen |
|---|
| contact affiliation | Laboratory of Lipid Metabolism and Cancer, Department of Oncology, KU Leuven |
| contact email | j.swinnen@kuleuven.be |
| lab head | |
| Lorenzo Venturelli |
|---|
| contact affiliation | KU Leuven |
| contact email | lorenzo.venturelli@kuleuven.be |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD070149 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD070149
- Label: PRIDE project
- Name: Integration of Multiple Spatial Omics Modalities Reveals Unique Insights into Molecular Heterogeneity of Prostate Cancer
