PXD070137-2

PXD070137 is an original dataset announced via ProteomeXchange.

Title	Single-cell transcriptome atlas reveals the underlying mechanism of kynurenic acid in regulation tumor immune microenvironment in glioblastoma
Description	We performed 4D-DIA approach to quantified the proteome of GBM tissues from two groups. An average of 8880 quantified proteins were identified in each sample. In order to further explore the regulation of Kyna on GMB-resident T cells at the protein level, we performed 4D-DIA proteome analysis of CD45+Cd3e+CD8+ cells sorted from GMB in Kyna-treated mice and control mice.
HostingRepository	iProX
AnnounceDate	2025-10-30
AnnouncementXML	Submission_2026-03-04_23:00:01.791.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Liming Sun
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2025-10-31 00:05:42	ID requested
1	2025-10-31 00:05:56	announced
⏵ 2	2026-03-04 23:00:02	announced	2026-03-05: Add info.

Chen D, Sun L, Chen J, Ye Z, Zhu X, Li H, Wu L, Zhao G, Zhang Q, Jiang G, Ji Y, Xue Y, Li H, Chen R, Zheng H, Zeng R, Yan D, Zhang Y, Li X, Yan J, Single-Cell Transcriptome Atlas Reveals the Underlying Mechanism of Kynurenic Acid in the Regulation of Tumor Immune Microenvironment in Glioblastoma. Adv Sci (Weinh), 13(5):e07705(2026) [pubmed]

submitter keyword: GMB, KYNA, 4D-DIA, Brain, CD8 T cells

Rong Zeng
contact affiliation	The First Affiliated Hospital of Zhengzhou University
contact email	zr@sibcb.ac.cn
lab head
Liming Sun
contact affiliation	The First Affiliated Hospital of Zhengzhou University
contact email	sunlm@ucas.ac.cn
dataset submitter

iProX dataset URI