PXD070103-1

PXD070103 is an original dataset announced via ProteomeXchange.

Title	Brachio-Cervical Inflammatory Myopathy: A Distinct Syndrome with Variable Association to Systemic Sclerosis — Insights from Clinical, Histopathological, and Transcriptomic Profiling
Description	Brachio-cervical inflammatory myopathy (BCIM) is a rare and under-characterized subtype of idiopathic inflammatory myopathies (IIM), marked by prominent upper limb and neck muscle involvement. Since its initial description in 2006, few studies have addressed its clinical spectrum or pathogenesis, and its potential overlap with systemic sclerosis (SSc) remains a matter of debate. Here, we aimed to characterize the clinical, histopathological, and molecular features of BCIM in a large multicenter cohort and assess whether BCIM constitutes a distinct entity within the IIM spectrum.
HostingRepository	PRIDE
AnnounceDate	2026-04-13
AnnouncementXML	Submission_2026-04-12_17:53:13.398.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Andreas Hentschel
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2025-10-30 08:01:10	ID requested
⏵ 1	2026-04-12 17:53:14	announced

Kleefeld F, Teran Gamboa J, Pinal-Fernandez I, Preusse C, Nelke C, Goebel HH, Mensch A, Mossakowski A, Miah MU, Diaz-Manera J, Torchia E, Bortolani S, Hentschel A, Funke A, Souvannanorath S, Authier FJ, Malfatti E, Gehrig J, Mammen AL, Casal-Dominguez M, De Winter J, De Ridder W, Ruck T, Schneider U, Roos A, Gallardo E, Tasca G, Stenzel W, Brachio-cervical inflammatory myopathy: multilevel clinical, histopathological and multi-omic analyses of a syndrome variably associated with systemic sclerosis. Acta Neuropathol, 151(1):(2026) [pubmed]

10.1007/s00401-026-03006-5;

submitter keyword: inflammatory myopathy, b cells, systemic clerosis,Myositis

Prof. Dr. Albert Sickmann
contact affiliation	Proteomics, Leibniz-Institut für analytische Wissenschaften -ISAS - e.V., Germany
contact email	albert.sickmann@isas.de
lab head
Andreas Hentschel
contact affiliation	Leibniz Institut für Analytische Wissenschaften
contact email	andreas.hentschel@isas.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD070103

PRIDE project URI

• PRIDE
  1. PXD070103
     1. Label: PRIDE project
     2. Name: Brachio-Cervical Inflammatory Myopathy: A Distinct Syndrome with Variable Association to Systemic Sclerosis — Insights from Clinical, Histopathological, and Transcriptomic Profiling