PXD070076 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomic Discovery of 2-AAA–Binding SAE1 and SUMO2/3-Related POLR2A |
| Description | This dataset contains two types of proteomics experiments. First, we performed affinity-based pulldown assays using biotin-conjugated 2-aminoadipic acid (2-AAA) to identify proteins that directly bind to this metabolite. Second, we conducted SUMO1 or SUMO2/3 immunoprecipitation followed by LC-MS/MS to determine SUMO-associated proteins that are regulated by AASS. These experiments provide proteomic evidence supporting metabolite-driven activation of SUMO signaling and SUMO2/3-associated POLR2A. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-08-04 |
| AnnouncementXML | Submission_2026-08-04_15:19:43.643.xml |
| DigitalObjectIdentifier | https://doi.org/10.6019/PXD070076 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Jung Seok Hwang |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | LTQ Orbitrap Elite |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-10-30 00:06:23 | ID requested | |
| ⏵ 1 | 2026-08-04 15:19:44 | announced | |
Publication List
Keyword List
| submitter keyword: SAE1, 2-aminoadipic acid (2-AAA), POLR2A,AASS, LC-MS/MS |
Contact List
| Sumin Kang |
|---|
| contact affiliation | Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory, Emory University School of Medicine, Atlanta, GA 30322, USA |
| contact email | smkang@emory.edu |
| lab head | |
| Jung Seok Hwang |
|---|
| contact affiliation | Emory Winship Cancer Institute |
| contact email | jhwan30@emory.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/08/PXD070076 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD070076
- Label: PRIDE project
- Name: Proteomic Discovery of 2-AAA–Binding SAE1 and SUMO2/3-Related POLR2A
