PXD070075 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomic characterization of synaptosomes and sarkosyl-insoluble protein inclusions from Alzheimer's disease patients |
| Description | Alzheimer’s disease is characterized by neuropathological accumulation of amyloid plaques and neurofibrillary tangles composed of amyloid-beta peptides and hyperphosphorylated tau protein, respectively. These neuropathological changes alter the function of neurons, including synaptic contacts between interacting neurons, eventually resulting in neuronal dysfunction and neurodegeneration. Here, we simultaneously isolated nerve terminals (synaptosomes) and larger sarkosyl-insoluble protein inclusions from postmortem brains from Alzheimer’s disease and control cases and performed proteomic and phosphoproteomic analyses. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-07-09 |
| AnnouncementXML | Submission_2026-07-09_08:56:23.411.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Sofie Blomberg Elmkvist |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | TMT6plex-126 reporter+balance reagent acylated residue; phosphorylated residue; iodoacetamide derivatized residue |
| Instrument | Q Exactive HF; Orbitrap Fusion Lumos; Orbitrap Exploris 480; Q Exactive HF-X |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-10-29 22:33:10 | ID requested | |
| ⏵ 1 | 2026-07-09 08:56:23 | announced | |
Publication List
Keyword List
| submitter keyword: Human, synaptosomes, brain, Alzheimer's disease, sarkosyl-insoluble fraction |
Contact List
| Martin Røssel Larsen |
|---|
| contact affiliation | Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark |
| contact email | mrl@bmb.sdu.dk |
| lab head | |
| Sofie Blomberg Elmkvist |
|---|
| contact affiliation | University of Southern Denmark |
| contact email | selmkvist@bmb.sdu.dk |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/07/PXD070075 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD070075
- Label: PRIDE project
- Name: Proteomic characterization of synaptosomes and sarkosyl-insoluble protein inclusions from Alzheimer's disease patients
