⮝ Full datasets listing
PXD070001-1
PXD070001 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Cross-species comparison between mouse kidney multi-omics and human genome-wide association studies highlights molecular features linked to urolithiasis risk |
| Description | Urolithiasis, a recurrent and increasingly prevalent disease worldwide, has a complex pathophysiology that hinders a comprehensive understanding. We performed a cross-species integrative analysis combining multi-omics profiling of kidneys from a calcium oxalate-induced mouse model with summary statistics from a large-scale human genome-wide association study. In the multi-omics analysis of urolithiasis mouse kidneys using RNA-seq, whole-cell proteome, and phosphoproteome, we identified 1,173 genes, 342 proteins, and 516 phosphorylated peptides that were differentially expressed in the calcium-induced mouse model compared with control mice. We utilized publicly available large-scale meta-GWAS summary statistics of urolithiasis to prioritize genes using enrichment analysis. Through the cross-species integration of mouse and human omics, we identified 46 candidate molecules with potential relevance to urolithiasis. We examined the expression and genetic associations of these 46 molecules in human urolithiasis, including CRYAB and SHROOM3, which showed differential expression in human renal papilla tissues with and without stones. Collectively, these results highlight a set of cross-species urolithiasis-related molecules that are supported by both expression and genetic evidence and are potentially involved in urolithiasis pathophysiology, offering insights for future functional validation and mechanistic investigations. |
| HostingRepository | MassIVE |
| AnnounceDate | 2026-05-04 |
| AnnouncementXML | Submission_2026-05-04_07:45:37.076.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Todd Greco |
| SpeciesList | scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090; |
| ModificationList | Phospho; Carbamidomethyl; Acetyl; Met-loss+Acetyl; Oxidation |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-10-28 19:14:49 | ID requested | |
| ⏵ 1 | 2026-05-04 07:45:38 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: oxalate-induced mouse model, phosphoproteome, total proteome, transcriptome, DatasetType:Proteomics |
Contact List
| Kazumi Taguchi | |
|---|---|
| contact affiliation | Department of Urology, University of Alabama at Birmingham |
| contact email | ktaguchi@uabmc.edu |
| lab head | |
| Ileana M Cristea | |
| contact affiliation | Department of Molecular Biology, Princeton University, USA |
| contact email | icristea@princeton.edu |
| lab head | |
| Yukinori Okada | |
| contact affiliation | Department of Genome Informatics, Graduate School of Medicine, the University of Tokyo |
| contact email | yuki-okada@m.u-tokyo.ac.jp |
| lab head | |
| Todd Greco | |
| contact affiliation | Princeton University |
| contact email | tgreco@princeton.edu |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v11/MSV000099680/ |
