PXD069962 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Quantitative proteomic analysis of nascent chromatin in early versus late S phase |
| Description | The progression of replication forks is tightly regulated to ensure accurate genome duplication. We have found that these forks display biphasic dynamics throughout an unperturbed S phase, characterized by slow elongation in early S that transitions to rapid elongation in late S. In this study, we identify the molecular factors underlying this change by quantitatively profiling the proteins associated with nascent chromatin in early versus late S phase. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-09-07 |
| AnnouncementXML | Submission_2026-09-07_04:27:15.314.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Kristie Lindsey Rose |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | isotope labeled residue; monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Orbitrap Exploris 480; Orbitrap Exploris 240 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-10-27 20:33:41 | ID requested | |
| ⏵ 1 | 2026-09-07 04:27:16 | announced | |
Publication List
| Jayaprakash D, Patterson JG, Mulvaney R, Dickinson Q, Lovejoy C, Lerdrup M, Rivera-Mulia JC, Cortez D, Bhowmick R, Topological stress regulates replication fork dynamics in unperturbed S phase. Nat Commun, 17(1):(2026) [pubmed] |
| 10.1038/s41467-026-73330-7; |
Keyword List
| submitter keyword: DNA replication, iPOND, cell cycle |
Contact List
| Kristie Lindsey Rose |
|---|
| contact affiliation | Vanderbilt University, Proteomics Core |
| contact email | kristie.rose@vanderbilt.edu |
| lab head | |
| Kristie Lindsey Rose |
|---|
| contact affiliation | Vanderbilt University |
| contact email | kristie.rose@vanderbilt.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/09/PXD069962 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD069962
- Label: PRIDE project
- Name: Quantitative proteomic analysis of nascent chromatin in early versus late S phase
