PXD069847 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | TMT-Based Quantitative Proteomic Profiling of Retina, Choroid, and Sclera in Albino and Pigmented Guinea Pigs to Investigate Myopia Susceptibility and Pathogenesis |
| Description | Myopia development and susceptibility vary across pigmentation backgrounds and ocular tissues, yet the underlying molecular mechanisms remain unclear. In this study, retina, choroid, and sclera were collected from albino and pigmented guinea pigs subjected to spontaneously developed hyperopia and myopia paradigms. Tissue proteins were labeled using 16-plex Tandem Mass Tags (TMT) and analyzed by Orbitrap LC-MS/MS to obtain tissue-resolved quantitative proteomes. Comparative analyses between Albino Hyperopia (AH), Pigmented Hyperopia (PH), and Albino Myopia (AM) groups aimed to identify protein networks and pathways associated with pigmentation heritage, extracellular matrix remodeling, and retinal signaling in myopia pathogenesis. The dataset provides peptide and protein-level quantification for three ocular tissues across all experimental conditions, enabling exploration of molecular mechanisms linking pigmentation and biomechanical regulation to eye growth control. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-08-24 |
| AnnouncementXML | Submission_2026-08-23_16:53:18.715.xml |
| DigitalObjectIdentifier | https://doi.org/10.6019/PXD069847 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Liqin Jiang |
| SpeciesList | scientific name: Cavia porcellus (Guinea pig); NCBI TaxID: NEWT:10141; |
| ModificationList | iodoacetamide derivatized residue |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-10-23 15:02:24 | ID requested | |
| ⏵ 1 | 2026-08-23 16:53:19 | announced | |
Publication List
| 10.26508/lsa.202503595; |
| 10.6019/PXD069847; |
| Jiang L, Wang L, Zhou L, Wu F, Ma JKK, Yu WS, Koh JH, Chia AW, Saw SM, Ghosh S, Barathi VA, Cross-tissue dual-omics analysis reveals molecular programs linked to myopia susceptibility and progression. Life Sci Alliance, 9(9):(2026) [pubmed] |
Keyword List
| submitter keyword: guinea pig, myopia, proteomics, sclera, choroid, retina |
Contact List
| Veluchamy Amutha Barathi |
|---|
| contact affiliation | Singapore Eye Research Institute, Singapore National Eye Centre, Duke-NUS, Medical School, Singapore, Singapore |
| contact email | amutha.b.veluchamy@seri.com.sg |
| lab head | |
| Liqin Jiang |
|---|
| contact affiliation | Singapore Eye Research Institute |
| contact email | jiang.liqin@seri.com.sg |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/08/PXD069847 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD069847
- Label: PRIDE project
- Name: TMT-Based Quantitative Proteomic Profiling of Retina, Choroid, and Sclera in Albino and Pigmented Guinea Pigs to Investigate Myopia Susceptibility and Pathogenesis
