PXD069791 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | CLPX acquires an iron-sulfur cluster to maintain mitochondrial unfolded protein response in cancer cells |
| Description | The proper function of UPRmt requires intact protein synthesis and mitochondrial import machineries. To explain why iron deficiency could inhibit UPRmt activity, we carried out proteomic assays on HepG2 cells to search for differentially-expressed mitochondrial proteins (DEMPs) associated with cytosolic and mitochondrial protein synthesis or mitochondrial import before and after DFX treatment. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-06-15 |
| AnnouncementXML | Submission_2026-06-14_16:15:35.597.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | 成全 黄 |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-10-22 13:04:09 | ID requested | |
| ⏵ 1 | 2026-06-14 16:15:36 | announced | |
Publication List
| 10.1038/s41467-026-74080-2; |
| Huang C, Zhang Y, Gao H, Song Y, Hu S, Sun C, Duan S, Ma D, Jiang X, Liu G, CLPX acquires an iron-sulfur cluster to sustain mitochondrial proteostasis in cancer cells. Nat Commun, 17(1):(2026) [pubmed] |
Keyword List
| submitter keyword: Human, MS, DFX, HepG2 |
Contact List
| Gang Liu |
|---|
| contact affiliation | Key Laboratory of Molecular Epigenetics of the Ministry of Education, Northeast Normal University, China; |
| contact email | liug268@126.com |
| lab head | |
| 成全 黄 |
|---|
| contact affiliation | Northeast Normal University |
| contact email | 3438897367@qq.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069791 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD069791
- Label: PRIDE project
- Name: CLPX acquires an iron-sulfur cluster to maintain mitochondrial unfolded protein response in cancer cells
