PXD069756-1

PXD069756 is an original dataset announced via ProteomeXchange.

Title	Lysine acylations in Staphylococcus aureus
Description	In this study, we employed multidimensional omics approaches, including proteomics, acetyl-omics, succinyl-omics, and lactyl-omics, to systematically investigate the effects of glucose treatment on protein expression and post-translational modifications in MRSA. Through the application of mass spectrometry, we identified 2,479 lysine acetylation sites, 1,353 lysine succinylation sites, and 89 lysine lactylation sites. Subsequent bioinformatics analyses indicated a significant enrichment of lysine acylations in ribosome-related functions and metabolism-associated pathways. Different types of lysine acylation exhibited distinct regulatory patterns. Further analysis demonstrated that lysine succinylation modulates the enzymatic activity of arsenate reductase, implicating its role in bacterial metabolic adaptation and functional regulation.
HostingRepository	iProX
AnnounceDate	2025-10-21
AnnouncementXML	Submission_2025-10-22_00:53:00.323.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Junyu Xu
SpeciesList	scientific name: Staphylococcus aureus; NCBI TaxID: 1280;
ModificationList	acetylated residue
Instrument	Orbitrap Ascend

Revision	Datetime	Status	ChangeLog Entry
0	2025-10-22 00:52:48	ID requested
⏵ 1	2025-10-22 00:53:00	announced

Dataset with its publication pending

submitter keyword: MRSA, Lysine acylations, Biofilm

Junyu Xu
contact affiliation	Chinese Academy of Sciences Shanghai Institute of Materia Medica
contact email	jyxu@simm.ac.cn
lab head
Junyu Xu
contact affiliation	Chinese Academy of Sciences Shanghai Institute of Materia Medica
contact email	jyxu@simm.ac.cn
dataset submitter

iProX dataset URI