PXD069717-1

PXD069717 is an original dataset announced via ProteomeXchange.

Title	Phosphorylation and acetylation in Candida albicans
Description	In this study, we employed an integrative multi-omics approach—including proteomics, phosphoproteomics, and acetylomics—to systematically investigate the effects of MRSA on protein expression and post-translational modification (PTM) patterns in C. albicans. Our results revealed that the presence of MRSA significantly altered the expression of virulence-associated proteins and reshaped the phosphorylation and acetylation levels of key proteins involved in critical signaling and metabolic pathways. These alterations were primarily linked to biological processes such as energy metabolism, metabolic reprogramming, and stress response. Functional enrichment analyses further suggested that these PTMs may play pivotal roles in regulating C. albicans pathogenicity and environmental adaptability. Additionally, in vitro enzyme activity assays demonstrated that MRSA-induced lysine acetylation modulated the activities of glyceraldehyde-3-phosphate dehydrogenase and homoisocitrate dehydrogenase, implicating this modification in metabolic adaptation and functional reprogramming of C. albicans. In conclusion, this study provides novel insights into the MRSA-mediated regulation of fungal physiology via post-translational modifications, offering a new theoretical basis for understanding fungal pathogenesis and developing improved anti-infective strategies in the context of bacterial–fungal interactions.
HostingRepository	iProX
AnnounceDate	2025-10-21
AnnouncementXML	Submission_2025-10-21_01:36:43.433.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Junyu Xu
SpeciesList	scientific name: Candida albicans; NCBI TaxID: 5476;
ModificationList	acetylated residue
Instrument	Orbitrap Ascend

Revision	Datetime	Status	ChangeLog Entry
0	2025-10-21 01:36:16	ID requested
⏵ 1	2025-10-21 01:36:43	announced

Dataset with its publication pending

submitter keyword: C. albicans, MRSA, quantitative proteomics, post-translational modification, phosphorylation, lysine acetylation

Junyu Xu
contact affiliation	Chinese Academy of Sciences Shanghai Institute of Materia Medica
contact email	XJY89089@163.com
lab head
Junyu Xu
contact affiliation	Chinese Academy of Sciences Shanghai Institute of Materia Medica
contact email	XJY89089@163.com
dataset submitter

iProX dataset URI