PXD069706 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Syntaxin 4 (STX4) protects islet -cells from cytokine-induced senescence |
| Description | Syntaxin 4 (STX4) is a plasma membrane SNARE protein known to facilitate insulin granule exocytosis in pancreatic β-cells. Recent studies have uncovered that STX4 also exerts protective effects against inflammatory and metabolic stress by stabilizing mitochondrial function and suppressing NF-κB activation. In this project, we investigated the role of β-cell STX4 in modulating the secretome and paracrine signaling under pro-inflammatory conditions associated with β-cell senescence and type 1 diabetes. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-02-25 |
| AnnouncementXML | Submission_2026-02-25_15:28:19.165.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Nathaniel Hansen |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Eclipse |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-10-20 22:54:20 | ID requested | |
| ⏵ 1 | 2026-02-25 15:28:19 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: SASP, inflammation,STX4, Type 1 Diabetes, beta cell senescence |
Contact List
| Dr Patrick Pirrotte |
|---|
| contact affiliation | Cancer & Cell Biology Division, Translational Genomics Research Institute, Phoenix, AZ Integrated Mass Spectrometry Shared Resource, City of Hope Comprehensive Cancer Center, Duarte, CA (lab head) |
| contact email | ppirrotte@tgen.org |
| lab head | |
| Nathaniel Hansen |
|---|
| contact affiliation | Translation Genomics Research Institute |
| contact email | nhansen@tgen.org |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/02/PXD069706 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD069706
- Label: PRIDE project
- Name: Syntaxin 4 (STX4) protects islet -cells from cytokine-induced senescence
