PXD069517-1

PXD069517 is an original dataset announced via ProteomeXchange.

Title	Fecal metaproteome profiles of celiac disease patients with poly-autoimmunity
Description	Twenty-eight subjects were selected for the study from among celiac disease patients regularly followed at the Medical Clinic of the University of Sassari. Celiac disease (CD) was diagnosed according to international guidelines. Patients were divided into two groups of 14 subjects based on the presence or absence of additional autoimmune diseases. Only autoimmune diseases confirmed by a specialist's certification were considered for the study. Further inclusion criteria included a body mass index (BMI) between 18 and 25 kg/m², a gluten-free diet (GFD) duration of one year or more, and an age between 18 and 60 years. Exclusion criteria were: (i) use of antibiotics, probiotics, or prebiotics in the 3 months prior to enrollment; (ii) a vegetarian or vegan diet; (iii) a history of malignancy, pregnancy, alcohol abuse, or drug addiction. Following a clinical evaluation, each patient provided a fecal sample. Additionally, three questionnaires were collected concerning: i) anamnestic and anthropometric data, ii) gastrointestinal symptoms, and iii) dietary habits and lifestyle.
HostingRepository	PRIDE
AnnounceDate	2025-10-16
AnnouncementXML	Submission_2025-10-16_02:47:07.195.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Alessandro Tanca
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; scientific name: human gut metagenome; NCBI TaxID: NEWT:408170;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2025-10-16 02:11:33	ID requested
⏵ 1	2025-10-16 02:47:07	announced

Dataset with its publication pending

submitter keyword: gut microbiome,celiac disease, autoimmunity, metaproteomics

Sergio Uzzau
contact affiliation	Department of Biomedical Sciences, University of Sassari, Sassari, Italy
contact email	uzzau@uniss.it
lab head
Alessandro Tanca
contact affiliation	University Hospital of Sassari, Sassari, Italy
contact email	aletanca@uniss.it
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD069517

PRIDE project URI

• PRIDE
  1. PXD069517
     1. Label: PRIDE project
     2. Name: Fecal metaproteome profiles of celiac disease patients with poly-autoimmunity