PXD069496 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Pervasive phenotypic effects of FBXO42 promoted by regulation of PP4 phosphatase |
| Description | F-box proteins are the substrate recognition modules of the SCF (SKP1–Cullin–F-box) E3 ubiquitin ligase complex. FBXO42, an understudied member of this family, has recently emerged as a modulator of key cellular processes, including cell cycle progression, DNA damage response and glioma stem cell survival. In this study, we define the function of FBXO42 as a major regulator of the protein phosphatase PP4. Phosphoprotein phosphatases (PPPs) have a broad array of substrates, hence necessitating tight regulation. We observe that FBXO42 ubiquitinates the PP4 complex to govern the assembly of regulatory and catalytic subunits with the net effect of restraining the latter’s phosphatase activity. FBXO42 depletion unleashes PP4 activity with broad cellular effects highlighting FBXO42 as a novel regulatory node in ubiquitin-mediated signalling for future therapeutic exploitation. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-02-23 |
| AnnouncementXML | Submission_2026-02-22_16:24:25.477.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | iolanda Vendrell |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-10-15 15:34:21 | ID requested | |
| ⏵ 1 | 2026-02-22 16:24:26 | announced | |
Publication List
| 10.1038/s44318-025-00675-y; |
| Yang H, Smith P, Ma Y, Southworth E, Gopala Krishna V, Salerno B, Rowland J, Loftus AEP, Grieco D, Vendrell I, Fischer R, Kessler BM, D'Angiolella V, Pervasive phenotypic effects of FBXO42 are promoted by regulation of PP4 phosphatase. EMBO J, 45(4):1332-1361(2026) [pubmed] |
Keyword List
| submitter keyword: cancer, Fbxo42, SCF, PPP phosphatases,ubiquitin |
Contact List
| Vincenzo D’Angiolella |
|---|
| contact affiliation | Edinburgh Cancer Research, CRUK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XU, UK |
| contact email | vdangio@ed.ac.uk |
| lab head | |
| iolanda Vendrell |
|---|
| contact affiliation | Target Discovery Institute, NDMRB |
| contact email | iolanda.vendrell@ndm.ox.ac.uk |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/02/PXD069496 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD069496
- Label: PRIDE project
- Name: Pervasive phenotypic effects of FBXO42 promoted by regulation of PP4 phosphatase
