PXD069466-1

PXD069466 is an original dataset announced via ProteomeXchange.

Title	A multi-omics resource for studying chronic hypoxia in pancreatic cancer
Description	The hypoxic tumor microenvironment is a critical driver of pancreatic ductal adenocarcinoma (PDAC) progression and chemoresistance. However, a comprehensive, multi-omics resource systematically profiling the molecular alterations induced by chronic hypoxia across diverse cellular components of PDAC is currently lacking. Here, we present a deeply characterized dataset generated from three PDAC cell lines, one pancreatic stellate cell line, and one normal pancreatic ductal epithelial cell line cultured under normoxic and chronic hypoxic (1% O₂) conditions. The dataset includes matched transcriptomic (RNA-Seq), proteomic, and phosphoproteomic profiles from biologically triplicated samples, all supported by phenotypic validation data confirming hypoxia-induced proliferation and gemcitabine resistance.
HostingRepository	iProX
AnnounceDate	2025-10-15
AnnouncementXML	Submission_2025-10-15_19:52:41.515.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Wantao Ying
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2025-10-14 19:18:20	ID requested
⏵ 1	2025-10-15 19:52:42	announced

Dataset with its publication pending

submitter keyword: Pancreatic cancer, hypoxia, proteomic, phospoproteomic

Wantao Ying
contact affiliation	Beijing Proteome Research Center
contact email	yingwantao@mail.ncpsb.org
lab head
Wantao Ying
contact affiliation	Beijing Proteome Research Center
contact email	yingwantao@mail.ncpsb.org
dataset submitter

iProX dataset URI