⮝ Full datasets listing
PXD069462-1
PXD069462 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Discovery of Novel MLKL PROTAC Degrader for the Treatment of Hepatocellular Carcinoma via Promoting Parthanatos |
| Description | Chen et al. discovered a highly potent and selective MLKL-targeted PROTAC C116 that effectively induces MLKL degradation and promotes parthanatos in HCC cells. More significantly, C116 was able to induce in vivo MLKL degradation and exerts anti-tumor activities in an orthotopic HCC tumor model, positioning it as a promising starting point for the treatment of HCC and a promising chemical probe for investigating the non-necroptotic functions of MLKL. |
| HostingRepository | iProX |
| AnnounceDate | 2025-10-14 |
| AnnouncementXML | Submission_2025-10-14_18:59:53.538.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Xinlei Wang |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | ZenoTOF 7600 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-10-14 18:59:33 | ID requested | |
| ⏵ 1 | 2025-10-14 18:59:54 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: HCC;MLKL |
Contact List
| Jing Ai | |
|---|---|
| contact affiliation | Shanghai Institute of Materia Medica |
| contact email | jai@simm.ac.cn |
| lab head | |
| Xinlei Wang | |
| contact affiliation | Shanghai Institute of Materia Medica |
| contact email | wangxinlei@simm.ac.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
