PXD069402 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Affinity-purification mass spectrometry on i) streptolysin O or C5a peptidase with human plasma or saliva; ii) human plasminogen with streptococcal proteins |
| Description | In this project, we tried to use affinity-purification mass spectrometry (AP-MS) to study host-pathogen protein interaction, focusing initially on two major virulence factors of group A streptococcus (GAS), streptolysin O (SLO) and C5a peptidase (C5AP) with the immediate host microenvironment (human plasma or saliva); next centering on one major pathogenic host factor of GAS, human plasminogen (PLG) molecule with streptococcal cell-wall associate proteins (CAP) or secreted proteins (SP). Quantitative MS was performed in combination with interaction analysis to pinpoint the high-confidence interactive partner to the corresponding baits. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-03-16 |
| AnnouncementXML | Submission_2026-03-16_14:10:38.227.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Di Tang |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; scientific name: Streptococcus pyogenes M1 GAS; NCBI TaxID: NEWT:160490; scientific name: Streptococcus pyogenes MGAS315; NCBI TaxID: NEWT:198466; |
| ModificationList | iodoacetamide derivatized residue |
| Instrument | Q Exactive HF-X |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-10-13 09:07:04 | ID requested | |
| ⏵ 1 | 2026-03-16 14:10:39 | announced | |
Publication List
| Piochi LF, Tang D, Malmstr, ö, m J, Karami Y, Khakzad H, Rapid Proteome-Wide Discovery of Protein-Protein Interactions With ppIRIS. Adv Sci (Weinh), ():e21310(2026) [pubmed] |
| 10.1002/advs.202521310; |
Keyword List
| submitter keyword: Group A streptococcus, protein-protein interaction, host-pathogen interaction,AP-MS |
Contact List
| Johan Malmström |
|---|
| contact affiliation | Division of Infection Medicine, Department of Clinical Sciences, Faculty of Medicine, Lund University, Klinikgatan 30, 222 42 Lund, Sweden; SciLifeLab, Integrated Structural Biology Platform, Structural Proteomics Unit Sweden, Lund University, Klinikgatan 32, 222 42 Lund, Sweden |
| contact email | johan.malmstrom@med.lu.se |
| lab head | |
| Di Tang |
|---|
| contact affiliation | Lund University |
| contact email | di.tang@med.lu.se |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/03/PXD069402 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD069402
- Label: PRIDE project
- Name: Affinity-purification mass spectrometry on i) streptolysin O or C5a peptidase with human plasma or saliva; ii) human plasminogen with streptococcal proteins
