⮝ Full datasets listing
PXD069376-1
PXD069376 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomic analysis of periodontal tissue reveals β-guanidinopropionic acid (β-GPA) mediated inhibition of the TLR4 pathway in a mouse model of hyperlipidemic periodontitis. |
| Description | This project aims to elucidate the molecular mechanisms by which the gut microbial metabolite β-guanidinopropionic acid (β-GPA) alleviates hyperlipidemic periodontitis (HPD). We performed Tandem Mass Tag (TMT) based quantitative proteomic analysis on periodontal tissues from HPD model mice versus those treated with β-GPA. The goal was to identify key differentially expressed proteins and uncover the protective signaling pathways modulated by β-GPA, ultimately identifying the TLR4-MyD88 axis as a primary therapeutic target. |
| HostingRepository | iProX |
| AnnounceDate | 2025-10-13 |
| AnnouncementXML | Submission_2026-06-08_18:03:02.113.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Jing Xu |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Astral |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-10-13 00:14:39 | ID requested | |
| ⏵ 1 | 2026-06-08 18:03:02 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Hyperlipidemic periodontitis |
| Periodontal tissue |
| β-GPA |
Contact List
| Min Hu | |
|---|---|
| contact affiliation | Hospital of Stomatology, Jilin University |
| contact email | humin@jlu.edu.cn |
| lab head | |
| Jing Xu | |
| contact affiliation | Hospital of Stomatology, Jilin University |
| contact email | 18843113828@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
