PXD069309 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | MS-based quantitative proteomic analysis of UVB irradiation in XPC-deficient keratinocytes |
| Description | Xeroderma Pigmentosum C (XPC) is a DNA damage recognition protein central to the global genome nucleotide excision repair (GG-NER) pathway, where it acts as a primary sensor of UV-induced DNA lesions. Loss-of-function mutations in the XPC gene lead to a photosensitive phenotype, with marked accumulation of unrepaired DNA damage and a dramatically elevated risk (10,000-fold) of skin cancer. This work aims at understanding the molecular signaling mechanisms associated with XP-C using genetically engineered human XPC knockout (KO) keratinocytes, the predominant cell type affected by UV radiation. We performed a mass spectrometry (MS)-based quantitative proteomic analysis, comparing XPC-wild-type and XPC-KO keratinocytes exposed or not to UVB for 24 hours. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-02-23 |
| AnnouncementXML | Submission_2026-02-22_16:24:26.770.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yohann Couté |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | alkylated residue; acetylated residue; monohydroxylated residue |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-10-10 02:35:52 | ID requested | |
| ⏵ 1 | 2026-02-22 16:24:32 | announced | |
Publication List
| 10.1038/s41598-026-37662-0; |
| Nasrallah A, Rezvani HR, Belmudes L, Bourgoin-Voillard S, Kobaisi F, Fayyad-Kazan M, Seve M, Cout, é Y, Sulpice E, Rachidi W, Type I interferon signaling defines a novel disease signature in xeroderma pigmentosum C human keratinocytes. Sci Rep, 16(1):6559(2026) [pubmed] |
Keyword List
| submitter keyword: Human, Keratinocytes, XP-C disease, nanoLC-MS/MS, UVB |
Contact List
| Yohann Couté |
|---|
| contact affiliation | EDyP |
| contact email | yohann.coute@cea.fr |
| lab head | |
| Yohann Couté |
|---|
| contact affiliation | EDyP |
| contact email | yohann.coute@cea.fr |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/02/PXD069309 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD069309
- Label: PRIDE project
- Name: MS-based quantitative proteomic analysis of UVB irradiation in XPC-deficient keratinocytes
