PXD069294-1

PXD069294 is an original dataset announced via ProteomeXchange.

Title	Proteomic and metabolomic analysis of immune-related adverse events in patients treated with PD-1 inhibitors
Description	As a class of immune checkpoint inhibitors (ICIs), programmed cell death protein-1 (PD-1) blockade have demonstrated remarkable efficacy in the treatment of various malignancies. However, their clinical application is constrained by the high incidence of immune-related adverse events (irAEs), which arise from nonspecific immune activation and can affect multiple organ systems, with severe cases posing life-threatening risks. This study integrated high-throughput proteomic and metabolomic analyses to systematically characterize the molecular features associated with irAEs in cancer patients receiving PD-1 inhibitor therapy. The results showed that, following the first treatment, patients who developed irAEs exhibited activation of the NF-κB pathway, along with lower baseline levels of SNRPA and higher expression of CD63. Metabolomic analyses further revealed that the kynurenine/tryptophan ratio was significantly elevated in the irAE group both at baseline and post-treatment compared with patients who did not develop irAEs. In addition, significant differences in the abundance of specific lipids were observed between the two groups prior to the administration of immunotherapy. Our findings systematically elucidates the immune response triggered by PD-1 blockade treatment, providing useful insights for the potential early identification and risk stratification of irAEs in cancer patients undergoing PD-1 blockade therapy.
HostingRepository	iProX
AnnounceDate	2025-10-10
AnnouncementXML	Submission_2025-10-10_01:18:53.542.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xiaoxuan Song
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos; Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2025-10-10 01:18:26	ID requested
⏵ 1	2025-10-10 01:18:54	announced

Dataset with its publication pending

submitter keyword: irAEs, proteomic, metabolomic, PD-1 inhibitor

Ruibing Chen
contact affiliation	School of Pharmaceutical Science and Technology, Faculty of Medicine, Tianjin University
contact email	rbchen@tju.edu.cn
lab head
Xiaoxuan Song
contact affiliation	School of Pharmaceutical Science and Technology, Faculty of Medicine, Tianjin University
contact email	songxx_9@tju.edu.cn
dataset submitter

iProX dataset URI