PXD069216 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | The C16orf87 protein is a subunit of the MIER corepressor complex controlling embryonic development and cell migration |
| Description | Histone modifications by histone deacetylases (HDACs) are essential for controlling chromatin structure and regulating gene expression. Functionally, HDACs act as enzymatic subunits within diverse multisubunit corepressor complexes, thereby targeting distinct sets of genes. Here, we identify C16orf87 as a previously uncharacterized functional subunit of the MIER corepressor complex that mediates HDAC1 and MIER1 protein interactions. Homozygous knockout of C16orf87 in human cells alters chromatin accessibility, reduces cell migration, and impairs embryonic development of zebrafish. Based on these findings, we propose renaming C16orf87 as HDAC Interacting Protein (HDIP), to reflect its newly revealed function. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-04-17 |
| AnnouncementXML | Submission_2026-04-17_09:03:51.097.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Mårten Larsson |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | iodoacetamide derivatized residue |
| Instrument | Orbitrap Fusion |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-10-08 14:04:31 | ID requested | |
| ⏵ 1 | 2026-04-17 09:03:51 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: HDAC1, MIER1, migration,C16orf87, chromatin, embryonic development |
Contact List
| Leif Andersson |
|---|
| contact affiliation | Derpatment of Medical Biochemistry, Uppsala University, Uppsala, Sweden. |
| contact email | Leif.Andersson@imbim.uu.se |
| lab head | |
| Mårten Larsson |
|---|
| contact affiliation | Uppsala University |
| contact email | marten.larsson@imbim.uu.se |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD069216
- Label: PRIDE project
- Name: The C16orf87 protein is a subunit of the MIER corepressor complex controlling embryonic development and cell migration
