PXD069155 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Alexander disease mutations differentially sensitize GFAP to oxidative damage and network disruption |
| Description | The type III intermediate filament protein GFAP plays key roles in astrocyte and brain homeostasis. Mutations in GFAP can result in Alexander’s disease (AxD), a severe neurodegenerative disease. Studies in AxD models indicate that oxidative stress may be an important pathogenic factor. Expression of certain GFAP AxD mutants in cells can provoke oxidative stress and potentially contribute to a pathogenic cycle since GFAP itself is an important target of oxidants. In order to understand the molecular mechanisms involved, we have carried out a detailed LC-MS/MS characterization of posttranslational modifications formed on recombinant GFAP wild-type and AxD mutants (R79C, R239C and E373K), in response to in vitro treatment with the biologically-relevant oxidants H2O2, HOCl and ONOOH. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-03-23 |
| AnnouncementXML | Submission_2026-03-22_17:43:12.070.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Per Hägglund |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | nitrated residue; disulfide crosslinked residues; 3'-chloro-L-tyrosine |
| Instrument | impact II |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-10-06 04:23:20 | ID requested | |
| ⏵ 1 | 2026-03-22 17:43:13 | announced | |
Publication List
| Goya-Iglesias N, H, ä, gglund P, Mart, í, nez-Cenalmor P, Nybo T, Lorentzen LG, Pajares MA, Davies MJ, P, é, rez-Sala D, Alexander disease mutations differentially sensitize glial fibrillary acidic protein (GFAP) to posttranslational modifications and network disruption by oxidants. Redox Biol, 92():104103(2026) [pubmed] |
| 10.1016/j.redox.2026.104103; |
Keyword List
| submitter keyword: Human, brain, disulfide, oxidation, GFAP |
Contact List
| Per Hägglund |
|---|
| contact affiliation | University of Copenhagen Faculty of Health and Medical Sciences Department of Biomedical Sciences Panum Institute University of Copenhagen |
| contact email | hagglundperm@gmail.com |
| lab head | |
| Per Hägglund |
|---|
| contact affiliation | University of Copenhagen |
| contact email | hagglundperm@gmail.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD069155
- Label: PRIDE project
- Name: Alexander disease mutations differentially sensitize GFAP to oxidative damage and network disruption
