PXD069118 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Label-free quantitative proteomics of Achilles and tail tendon fascicles from WT and VHL KO mice |
| Description | Tendon integrity depends on controlled extracellular matrix production and adaptation to mechanical load. Dysregulated hypoxia-inducible factor 1α (HIF1α) signaling has been linked to human tendon disease. To investigate the effects of chronic HIF1α activation and to compare responses between load-bearing Achilles tendons and positional tail tendon fascicles, we generated a tendon-specific VHL knockout in SCX-positive cells and performed label-free proteomics to characterize matrix remodeling. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-11-24 |
| AnnouncementXML | Submission_2025-11-24_02:54:03.894.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Greta Moschini |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | LTQ Orbitrap |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-10-03 06:34:59 | ID requested | |
| ⏵ 1 | 2025-11-24 02:54:04 | announced | |
Publication List
Keyword List
| submitter keyword: LC-MSMS,Mouse, Tendon, VHL KO |
Contact List
| Jess Gerrit Snedeker |
|---|
| contact affiliation | Laboratory of Orthopedic Biomechanics, ETH Zurich (Department of Health Sciences and Technology) and University of Zurich (Medical Faculty) |
| contact email | jess.snedeker@hest.ethz.ch |
| lab head | |
| Greta Moschini |
|---|
| contact affiliation | ETH Zürich |
| contact email | gretam@ethz.ch |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/11/PXD069118 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD069118
- Label: PRIDE project
- Name: Label-free quantitative proteomics of Achilles and tail tendon fascicles from WT and VHL KO mice
