PXD069057-1

PXD069057 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	HDX-MS analysis of p110a in complex with regulatory subunits
Description	HDX-MS was used to map the changes in conformational dynamics in the catalytic subunit of PI3Ka, p110a, in complex with the following five reguatory subunits: p85a, p85b, p55g, p55a, p50a. Apo and pY activated states were also compared between the three splice variants encoded by PIK3R1. No significant changes were observed in p110a between any of the regulatory subunits in the apo state.
HostingRepository	PRIDE
AnnounceDate	2025-11-20
AnnouncementXML	Submission_2025-11-20_12:33:32.679.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	John Burke
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	impact HD; impact II

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-10-01 16:30:38	ID requested
⏵ 1	2025-11-20 12:33:33	announced

Publication List

10.1016/j.jbior.2025.101128;
Barlow-Busch I, Walsh EE, Nyvall HG, Burke JE, are not differentially modulated by regulatory subunit isoforms. Adv Biol Regul, ():101128(2025) [pubmed]

10.1016/j.jbior.2025.101128;

Barlow-Busch I, Walsh EE, Nyvall HG, Burke JE, are not differentially modulated by regulatory subunit isoforms. Adv Biol Regul, ():101128(2025) [pubmed]

Keyword List

submitter keyword: HDX-MS, PI3Ka, p85

submitter keyword: HDX-MS, PI3Ka, p85

Contact List

Dr. John E. Burke
contact affiliation	University of Victoria
contact email	jeburke@uvic.ca
lab head
John Burke
contact affiliation	University of Victoria
contact email	jeburke@uvic.ca
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/11/PXD069057
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/11/PXD069057

PRIDE project URI

Repository Record List

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